The Cancer Genome Atlas (TCGA) provides an unprecedented opportunity to take an integrated approach toward a systems level understanding of regulatory disruptions in cancer. Such disruptions and their consequences are intertwined within complex dynamical networks through a multitude of interactions among different types of molecules. Understanding such relationships requires multivariate analysis methods that can be effective in the context of highly heterogeneous data, measurement uncertainty, and missing data.

Research

Development of novel computational approaches for analyzing large-scale heterogeneous data.

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Cancer Studies

Actively participating and contributing to several TCGA tumor Analysis Working Groups.

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Software

Web-based interactive visualization and exploratory tools, and computational infrastructure that promotes collaborative research.

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News & Events

July 2014

The TCGA Research Network published a study on Gastric Cancer in Nature with substantial contributions from members of our center. Dr. Shmulevich served as one of the co-chairs of the study group. One of the main results of the paper is that gastric tumors tend to fall into one of four subtypes. The treatment of gastric cancer may improve with therapy targeted against specific subtypes. Associations within the dataset of 295 tumors can be viewed in Regulome Explorer.

October 2013

A position paper is published in Nature Genetics describing The Pan-Cancer initiative, which compares the first 12 tumor types profiled by The Cancer Genome Atlas (TCGA) project. The data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. Nature also created a focused resource with threads and links to 18 pan-cancer papers. A related article also appeared in the Los Angeles Times.

We took part in the TCGA study of glioblastoma, published in Cell. The project released a new catalog of genetic-mutation data for nearly 600 glioblastoma cases. We also developed a companion open-access software tool (Micro) that allows researchers to study the correlations between microRNAs and proteins in detail.

September 2013

We have been awarded a grant from Washington State's Life Sciences Discovery Fund to develop web-based tools for analyzing cancer genetic data to advance understanding of tumor biology, accelerate new discoveries, and in the long term, facilitate personalized therapy. Here is the Press Release from LSDF. There was also an article on GenomeWeb about this award.

May 2013

New paper published in Nature on "Integrated genomic characterization of endometrial carcinoma" as part of the TCGA network.

April 2013

We were awarded the first prize in the YarcData Graph Analytics Challenge. The topic of our entry was drug repurposing for cancer and uses data from TCGA, PubMed, and other databases.

February 2013

Investigators from our GDAC have published the discovery and characterization of FGFR3-TACC3 fusion in 8% of glioblastoma in "The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma".

New paper published in Cancer Cell on "Integrated Analyses Identify a Master MicroRNA Regulatory Network for the Mesenchymal Subtype in Serous Ovarian Cancer" as part of the TCGA network. The cover of Cancer Cell features the article, with a graphic depicting the analysis.

November 2012

Researchers at our center attended and presented at the 2nd Annual TCGA Scientific Symposium. The symposium was co-chaired by Dr Ilya Shmulevich. Dr Brady Bernard and Hector Rovira gave a talk on Genespot: A Portal for Interactive Gene-Centric Exploration of The Cancer Genome Atlas. Dick Kreisberg presented a workshop on Regulome Explorer.

October 2012

New paper published in Nature on "Comprehensive molecular portraits of human breast tumours" as a part of the TCGA network. An article related to the work was published in the New York Times.

September 2012

The TCGA project published a Case Study on "The New Genomic Bottleneck and How the Cloud Might Widen It" in which Dr Ilya Shmulevich is interviewed on his lab’s efforts to analyze genomic information using large computational clusters with cloud infrastructure on demand.

July 2012

New paper published in Nature on "Comprehensive molecular characterization of human colon and rectal cancer" as part of the TCGA network. An article related to the work was featured on the home page of the New York Times.

June 2012

Our work was featured during the Compute Engine keynote presentation at the Google I/O 2012 conference.



The keynote, delivered by Urs Hölzle, Senior Vice President of Infrastructure at Google, introduced Google Compute Engine. He demonstrated how RF-ACE, a machine learning algorithm that learns associations among genomic and clinical features, can be scaled to 600,000 cores across Google’s global data centers and the results visualized using a version of Regulome Explorer. A case study published by Google discusses the integration with Compute Engine.

May 2012

Regulome Explorer is featured in this article where ISB founder Dr. Leroy Hood talks about the application of mathematics to biological research.

March 2012

Regulome Explorer is covered in this story about online tools available for analyzing TCGA data.

December 2011

Addama described in this technology feature on adaptive technologies for systems biology data integration.

October 2011

New paper published in the Journal of the American Medical Association on "Association of BRCA1 and BRCA2 Mutations With Survival, Chemotherapy Sensitivity, and Gene Mutator Phenotype in Patients With Ovarian Cancer" showing that women with high-grade ovarian cancer live longer and respond better to platinum-based chemotherapy when their tumors have BRCA2 genetic mutations.

There was also a related editorial published in JAMA.